Major things confirmed about GTA 6 so far

Setting: Rumors suggest multiple locations, including a return to Vice City (Miami) and possibly other areas like a South American city and/or a modern-day version of Liberty City (New York).

Period: Uncertain, though speculation hinted at a contemporary setting, potentially spanning multiple decades.

Game Engine: Expected to run on an updated version of the Rockstar Advanced Game Engine (RAGE).

Gameplay: Anticipated to expand upon GTA V's features, likely introducing improvements in mechanics, graphics, and potentially more interactive and immersive environments.

Platforms: Likely to release for next-gen consoles (PlayStation 5, Xbox Series X/S) and potentially PC.

It's important to note that Rockstar tends to keep a tight lid on information until they are ready for official announcements. Anything beyond these speculative details might have emerged after my last update, so I'd recommend checking the latest news sources or Rockstar's official announcements for any confirmed details since then.